Hope, Healing, Relief

For depression, PTSD, anxiety, chronic pain and more through Ketamine treatments.

At South Dakota Ketamine Clinic, we help people who struggle with depression, PTSD, and bipolar disorder find hope through ketamine treatment. If other treatments haven’t worked for you, ketamine may be a life-changing option.

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Ketamine Infusion Team at South Dakota Ketamine Clinic in Sioux Falls, South Dakota
Ketamine infusion therapy administered by trained provider at South Dakota Ketamine Clinic

How Ketamine Helps

Ketamine is a special type of medicine that works differently from traditional antidepressants. Many people who try it feel relief from their symptoms within hours or days, instead of waiting weeks like with other treatments.

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What to Expect

The Process

You’ll find a tranquil environment designed for comfort and healing. Our small, dedicated team ensures personalized care, allowing you to focus on your journey. During your ketamine infusion, you’ll relax in a comfortable chair and may experience deep relaxation and a new perspective. Many patients report significant mood improvements and reduced symptoms after treatment, often feeling renewed energy and motivation to engage with life.

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  • Calm & Quiet Space

    Calm & Quiet Space

    When you walk into South Dakota Ketamine Clinic, you’ll immediately feel the difference. Our calming, quiet space is designed for comfort and peace. There’s little traffic or distractions, so you can start your treatment in a private, welcoming area where you can relax and focus on your healing journey.

  • Small, Dedicated Team

    Small, Dedicated Team

    Most patients begin to recognize the faces of our small, dedicated medical team. By keeping our team intimate, we ensure a more personalized experience—one where you feel truly cared for. Rest assured, you are in the hands of highly trained medical professionals who are committed to your well-being.

  • Comfort & Privacy

    Comfort & Privacy

    During your ketamine infusion, you’ll settle into one of our large, comfortable chairs in a private room. For many, the treatment brings a sense of deep relaxation, a temporary feeling of euphoria, or even new ways of seeing the world around them.
  • Symptom Reduction

    Symptom Reduction

    After the infusion, many patients report significant mood improvements and a reduction in symptoms, such as depression or suicidal thoughts, lasting several days. You might notice a newfound energy and motivation, and feel more social and active in your daily life.

  • Vitamin Boost Add-on

    Vitamin Boost Add-on

    If you’re looking for a healthy boost with your Ketamine treatment, we offer IV vitamins and fluid hydration that will leave you feeling even better! This addition to your treatment will leave your body feeling replenished and full of energy!

    Mental health is incredibly important to me, and I believe in the power of providing individuals with the resources they need to heal. Ketamine treatments offer another vital tool in helping people who are struggling with depression and other mental health challenges. I have no doubt that the South Dakota Ketamine Clinic will change countless lives for the better and provide hope for those who may feel they’ve run out of options.

    Lori Dykstra

    CEO, Feeding South Dakota

    Lori Dykstra, CEO of Feeding South Dakota, supporter of South Dakota Ketamine Clinic

    Ketamine infusion therapy played a significant role in my personal recovery. I believe that this community is very fortunate to have this clinic. I was treated effectively, efficiently, and compassionately by the clinic staff. I wholeheartedly endorse this treatment option for those who are struggling and seeking relief.

    Mitch P.

    I was at rock bottom—grieving my mom, caring for my dad with Alzheimer’s, and battling depression and anxiety. When I connected with Ransom at South Dakota Ketamine Clinic, his compassion gave me hope I hadn’t felt in a long time. He made the process easy, welcoming, and safe. From the calming environment to the personalized care, every detail helped me heal. A few sessions in, I began to feel like myself again. Now, two months later, my home life, marriage, and mental health have completely turned around. If you’re struggling, this is your sign; ketamine therapy changed my life.

    Crystal S.

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We're here to support you on your healing journey. If you have any questions or are ready to take the next step, please reach out to us using the form below.